Title: DISENTANGLING MANY-BODY QUANTUM SYSTEMS AND LARGE-SCALE LINEAR ALGEBRA In this talk I want to show how many important questions of quantum many-body physics (solid state physics, quantum optics) naturally lead to a highly efficient description of quantum states by sets of matrices whose manipulation involves large-scale linear algebra of sparse matrices. I will illustrate the various challenges by current physical problems from solid state physics and quantum optics and would like to try to give a flavour why theoretical physicists would be interested in insights from computer science and numerical mathematics to tackle such problems.